Eric E. Sigmund1, Steven Baete1, Gene Y. Cho1, Dabang Sui1, Thompson Ukpebor1, Kecheng Liu2, Jane Kwon1, Kellyanne McGorty1, Jenny Bencardino1
1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Siemens Medical Systems
Skeletal muscle pathologies can have both microstructural and microvascular underpinnings to which diffusion-weighted imaging can be made sensitive through the intravoxel incoherent motion (IVIM) approach. We performed IVIM in healthy calf muscles at 3 T both before and after treadmill exertion, and evaluated the biomarkers of tissue diffusivity, perfusion fraction, and pseudodiffusivity in 7 different muscle compartments and three orthogonal directions. The largest and most significant changes occurred for perfusion fraction, which isotropically increased by ~50%. Results are discussed in the context of muscle physiology and the sensitivities of diffusion contrast.