Greg O. Cron1, 2, Merit El-Maadawy3, Joel Werier1, 2, Rebecca E. Thornhill1, 2, Robert Chatelain1, Elizabeth Henderson1, Claire Foottit1, Ian Camero
1The Ottawa Hospital, Ottawa, ON, Canada; 2The University of Ottawa, Ottawa, ON, Canada; 3Mansoura University Hospitals, Mansoura, Egypt
Measurement of tracer kinetic parameters via dynamic contrast-enhanced (DCE) MRI is a promising technique for evaluating musculoskeletal tumor aggressiveness. Standardization and validation studies for DCE-MRI in musculoskeletal tumors have been lacking, however. The purpose of this study was to validate DCE-MRI in musculoskeletal tumors by comparing to DCE-computed tomography (CT) in the same patients. We observed reasonable agreement in tracer kinetic parameters measured with CT and MRI. In particular, Ktrans had very similar mean values and showed good correlation on a case-by-case basis. This represents an important step forward for quantification of DCE-MRI for these tumors.