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Abstract #3378

CEST MRI as a Potential Imaging Biomarker of Mitochondrial Metabolic State of Breast Cancer

MAGNA25Kejia Cai1, He N. Xu2, Mohammad Haris1, Anup Singh1, Ravinder Reddy1, Lin Z. Li2

1CMROI, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Dapartment of Radiology, University of Pennsylvania, Philadelphia, PA, United States


Predicting breast tumor metastatic potential remains a challenge in cancer research and clinical practice. Previous studies indicate that tumor redox ratio heterogeneity (rim-core difference) serves as a biomarker of tumor metastatic potential. In this study, we demonstrated that CEST MRI showed tumor core-rim heterogeneity correlating with the mitochondrial redox state whereas T1 and T2 weighted MRI did not. CEST MRI of breast tumor metabolites (especially Glu) may be used as a potential non-invasive imaging biomarker of mitochondrial redox state for predicting breast cancer metastatic potential.