Xiufeng Li1, Jeffrey S. Spence2, 3, Subhendra N. Sarkar4, David E. Purdy5, Gregory J. Metzger1, Robert W. Haley3, Richard W. Briggs, 36
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, United States; 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; 4Radiology, Harvard Med. School, Beth Israel Deaconess Med. Ctr., Boston, MA, United States; 5Siemens Healthcare, Malvern, PA, United States; 6Radiology, UT Southwestern Medical Center, Dallas, TX, United States
Measuring hippocampal longitudinal sub-region perfusion has significant clinical relevance, with potential for better diagnosis and understanding of healthy and pathological hippocampal physiology. To evaluate the reliability of measuring hippocampal longitudinal sub-region perfusion using arterial spin labeling (ASL) imaging, measurement errors due to both random spatial noise and temporal physiological noise in OPTIMAL FAIR ASL studies of rCBF were evaluated. Results indicate that hippocampal longitudinal sub-region perfusion can be reliably measured using ASL imaging.