Renate Gruner1, 2, Ingfrid Salvesen Haldorsen1, Torfinn Taxt1, 2, Helga Salvesen, 23
1Dept of Radiology, Haukeland University Hospital, Bergen, Norway; 2University of Bergen, Bergen, Norway; 3Dept of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
The purpose was to explore the feasibility of dynamic contrast enhanced MRI (DCE-MRI) in endometrial carcinomas and investigate possible correlation between perfusion derived parameters and the apparent diffusion coefficient (ADC) estimated from diffusion weighted imaging. Endometrial carcinoma is the most common gynecological malignancy in industrialized countries, and the incidence is increasing. Tracer kinetic modeling was performed using the adiabatic approximation model of Johnson and Wilson (aaJW). The endometrial carcinomas displayed lower post contrast enhancement and faster contrast was-out compared to normal myometrium. These first results in ten patients show that DCE-MRI acquisition and modeling in highly feasible in endometrial carcinomas.