Ali Tabesh1, Jens H. Jensen1, Joseph A. Helpern1, 2
1Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States; 2Neurosciences, Medical University of South Carolina, Charleston, SC, United States
The accuracy of diffusional kurtosis imaging (DKI) in resolving crossing fiber bundles was compared via simulations to those of diffusion spectrum imaging (DSI) and Q-ball imaging (QBI). The accuracies of these techniques and DTI were also investigated when a dominant fiber bundle intersects with an admixture of a subdominant bundle. The simulations utilized the analytical orientation distribution function representation for each technique. DSI provided the most accurate estimates in both comparisons, whereas QBI with b = 4000 s/mm2 and DKI with b = 2000-2500 s/mm2 offered similar accuracies. Finally, DKI was superior to DTI in estimating the dominant fiber bundle direction.