Paola Valsasina1, Maria A. Rocca, Letizia Panicari, Gianna Riccitelli, Flavia Mattioli2, Ruggero Capra3, Chiara Stampatori2, Giancarlo Comi4, Massimo Filippi1
1Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy; 2Clinical Neuropsychology Unit, Spedali Civili of Brescia, Brescia, Italy; 3Multiple Sclerosis Centre, Spedali Civili of Brescia, Brescia, Italy; 4Department of Neurology, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, Italy
In this study, we used seed-voxel correlation analysis to investigate resting state (RS) functional connectivity (FC) of the anterior cingulate cortex (ACC) in two groups of patients with multiple sclerosis (MS): a treatment group, performing 12 weeks of cognitive rehabilitation of attention/information processing and executive functions, and a control group. At follow up, increased FC between the ACC, the right middle frontal gyrus and inferior parietal lobe was detected in the treated group, while decreased FC between the ACC, the cerebellum and the middle temporal gyrus was detected in the control group.