Ryo Sakamoto1, Tomohisa Okada1, Koji Sakai2, Akira Yamamoto1, Mitsunori Kanagaki1, Seiko Kasahara1, Emiko Morimoto1, Takeshi Sawada1, Thorsten Feiweier3, Da
1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Department of Human Health Science, Kyoto University Graduate School of Medicine, Kyoto, Japan; 3Siemens AG, Erlangen, Germany
High-resolution DTI with reasonable reproducibility in acceptable scan time for the hippocampus and structures at its vicinity are highly important for detection of faint pathological changes of neurological disorders. Both of two latest high-resolution DTI sequences, single-shot Advanced (Adv)-DTI using a single refocusing RF with distortion correction and multi-shot readout segmented (RS)-DTI, showed high reproducibility of ADC. RS-DTI had less distortion and was considered more accurate for population-based analysis. For FA, Adv-DTI was superior, probably due to higher SNR. In either case, CSF had much higher variance and it had better be excluded from further analysis such as voxel-based morphometry.