Clarisse Longo dos Santos1, 2, Oliver Riff1, Claire Ewenczyk3, 4, Jerme Yelnik3, 5, Cecile Gaudebout3, 4, Eric Bardinet2, 6, Linda Marrakc
1Neurospin, CEA/I2BM, Gif-sur-Yvette, France; 2CR-ICM / CENIR, Paris, France; 3CR-ICM / AP-HP, Groupe Hospitalier Piti-Salptrire, Facult de Mdecine, Paris; 4Centre dInvestigation Clinique, Fdration des Maladies du Systme Nerveux, France; 5INSERM; 6CNRS-UMR7225, France
We have combined structural and diffusion magnetic resonance imaging to investigate the connectivity of the pedunculopontine nucleus (PPN) region in Parkinson's disease and Progressive supranuclear palsy patients. A total of 87 participants were recruited, including 45 patients PD, 12 patients PSP and 30 age-matched controls. Images were acquired using a 3T (Trio Siemens; T1; T2; diffusion 60 directions b-value 1500s/mm) and a 7T (Trio Siemens; T2* 0.6x0.6x0.6mm3).