Yosef A. Berlow1, 2, Steve Kohama3, James Pollaro1, Manoj Sammi1, William Rooney1, 2
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States; 3Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, United States
This study measured age associated brain iron accumulation in Japanese macaques (JM) and humans. Eighty-eight JM and 43 healthy human control subject were included. Proton density and T2-weighted TSE images were used to calculate R2 maps. The effects of age on R2 were modeled in caudate, putamen and pallidum. JM R2 values increase rapidly during the first two decades of life and then begin to plateau at levels that are much greater than those seen in humans. These findings suggest that JM accumulate brain iron throughout their adulthood and attain brain iron concentrations that are much greater than humans.