Valerie C. Anderson1, David P. Lenar1, Phillip C. Berryhill1, Joseph F. Quinn2, Jeffrey A. Kaye2, William D. Rooney3
1Neurological Surgery, Oregon Health & Science University, Portland, OR, United States; 2Neurology, Oregon Health & Science University, Portland, OR, United States; 3Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States
1H2O R1 values were determined in the superior lateral ventricles of 34 healthy older subjects (68 6 yrs; 13 M, 21 F) at 7T before and 3 times (within 50 min) after gadoteridol (CR) administration. Fractional CSF volume was determined by segmentation of structural T1-w images. A significant inverse correlation of pre-CR R1 values with ventricular volume was observed. R1 values increased at each time point after injection of CR, confirming that administration of CR increases R1 in the ventricles of the human brain. R1 values after CR administration were increased significantly more in women than men.