Kiterie M.E. Faller1, Craig A. Lygate1, Mahon L. Maguire1, Debra J. Medway1, Victoria L. Thornton1, Stefan Neubauer1, Jurgen E. Schneider1
1Cardiovascular medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom
The failing heart is characterised by a decrease in myocardial creatine, adenine nucleotides, and high-energy phosphate metabolites. In a mouse model of permanent coronary artery ligation, we tested the hypothesis whether simultaneous elevation of myocardial creatine and ribose would be beneficial by increasing cardiac energy availability. Using a combination of 1H-MRS, 31P-MRS, cine-MRI to measure total creatine, phosphocreatine (PCr)/ATP ratio, cardiac function/mass and infarct size, we did not observe any beneficial or deleterious effect of this therapeutic approach in post-infarct left ventricular remodelling or function.