Jie Zheng1, David Muccigrosso1, Adil Bashir1, Pradeep Gupte2, Robert J. Gropler1
1Washington University, Saint Louis, MO, United States; 2Rockland Technimed, Ltd, United States
Quantification of myocardial oxygen consumption using 17O-CMR was validated in this study using microsphere measurements and blood sampling in normal dogs. Further evaluation was performed in dogs with severe coronary artery stenosis. The oxygen consumption rates measured by 17O-CMR strongly agreed with reference values. Increases in oxygen consumption rate in severely ischemic regions reflect increased oxygen extraction to compensate substantial loss in oxygen supply, as expected.