Jeremy
R. McGarvey1, 2, Walter R.T. Witschey, 23,
Kevin J. Koomalsingh2, Norihiro Kondo2, Manabu Takebe2,
Gerald A. Zsido2, Melissa M. Levack2, Christen M. Di
1Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, United States; 2Gorman Cardiovascular Research Lab, Harrison Department of Surgical Research, Glenolden, PA, United States; 3Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA, United States; 4Department of Radiology, University Medical Center Freiburg, Freiburg, Germany; 5Department of Radiology, Northwestern University School of Medicine, Chicago, IL, United States
Development of ischemic cardiomyopathy is complex pathophysiologic process that is both challenging to describe and treat. Ischemic insult results in an increase in the zero-pressure volume (Vo) and residual volume, as defined by pressure-volume relationships and flow-sensitive 4D MRI respectively. A directed therapy that restores the V0 of the infarcted area has yet to be introduced or evaluated. We describe the flow changes associated with a novel epicardial active assist device. Using 4D flow-sensitive MRI, we have found that both systolic and diastolic flow is increased in the area adjacent to the infarct while being assisted, when compared to baseline.