Bram F. Coolen1, Desiree Abdurrachim1, Abdallah GA Motaal1, Klaas Nicolay1, Gustav J. Strijkers1, Jeanine J. Prompers1
1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
This study presents the use of retrospectively triggered CINE MRI for high spatio-temporal resolution diastolic function measurements in mice. A temporal resolution < 2 ms could be reached allowing accurate determination of the E and A diastolic filling rates. Using this technique, subtle reductions in diastolic function were observed in diabetic db/db mice compared to non-diabetic db/+ mice.