Hooman Hamedani1, Kiarash Emami1, Stephen J. Kadlecek1, Yi Xin1, Puttisarn Mongkolwisetwara1, Biao Han1, Harrison McAdams2, Masaru Ishii3, G. Wilson Miller4
1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Biological Basis of Behavior Program, University of Pennsylvania, Philadelphia, PA, United States; 3Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States; 4Radiology, University of Virginia, Charlottesville, VA, United States; 5Medicine, University of Pennsylvania, Philadelphia, PA, United States
Ten healthy non-smokers and twenty asymptomatic smokers participated in a hyperpolarized 3He ADC and pAO2 MRI imaging. 12 slices with thickness of 13mm were acquired for each subject during 12-second breath-hold with a reasonable spatial resolution. Before each MRI session, a pulmonary function test was performed. Imaged ADC and pAO2 distributions of whole-lung were regressed on PFT results and ANNOVA test was performed to study the power of discriminatory of MRI metrics in distinguishing the smokers from nonsmokers.