Nathan S. Artz1, Catherine DG Hines2, Jens-Peter Kuhn1, Alejandro Roldan-Alzate1, Rashmi Agni3, Steven Brunner4, Guang-Hong Chen4, Scott B. Reeder1, 4
1Department of Radiology, University of Wisconsin, Madison, WI, United States; 2Pharmaceuticals, Merck & Co., Inc, Philadelphia, PA, United States; 3Department of Surgical Pathology, University of Wisconsin, Madison, WI, United States; 4Department of Medical Physics, University of Wisconsin, Madison, WI, United States
Quantitative MRI methods have shown great promise as non-invasive biomarkers of hepatic steatosis, with validation studies performed in phantoms, animal models, and patients. However, CT and increasingly Dual-Energy CT (DECT), is used for most advanced imaging studies of the abdomen. The purpose of this study was to compare MRI and DECT for fat quantification using tissue triglyceride (TG) concentration as the reference, in an ob/ob mouse model. Excellent correlation (r >= 0.93,p<0.001) was observed for both CT attenuation (HU) and MRI fat-fraction compared with tissue TG and each other. Other DECT measurements demonstrated good, but inferior, correlation with TG and MRI.