Jochen Keupp1, Holger Eggers1
1Philips Research, Hamburg, Germany
Amide proton transfer (APT), a powerful technique for molecular imaging of endogenous proteins, is based on an asymmetry analysis of RF saturation frequency offsets acquired around the water resonance, which needs precise B0 homogeneity correction. While fast spin-echo (FSE) based APT has superior contrast-to-noise ratio, the previously shown multi-echo APT acquisition with intrinsic Dixon-type B0 mapping/correction is restricted to gradient-echo sequences. We propose a FSE-Dixon APT technique with varied echo time shifts, using iterative Dixon reconstruction across different positive saturation frequency offsets for intrinsic B0 mapping and correction. Feasibility in the human head is demonstrated using a clinical 3T scanner.