Chao Xu1, 2, Christian Labadie, 23, Andr Pampel2, Jochen B. Fiebach1, Harald E. Mller2
1Center for Stroke Research Berlin (CSB), Charite-Universitaetsmedizin Berlin, Berlin, Germany; 2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 3Laboratoire de Spectromtrie Ionique et Molculaire, Universit Claude-Bernard Lyon 1, Villeurbanne, France
Chemical exchange saturation transfer (CEST) permits the detection of dilute labile proteins to allow pH-weighted imaging. However, clinical applications of the technique are currently limited due to time and specific absorption rate (SAR) restrictions. We developed a three-dimensional (3D) pulse sequence with low SAR and embedded field map information. Potential application for detecting ischemic acidosis is demonstrated in a stroke patient imaged on the second day after symptom onset.