Vickie Zhang1, 2, Robert Bok1, Subramaniam Sukumar1, Adam Cunha3, I-C. Hsu3, Jean Pouliot, 23, Daniel B. Vigneron1, 2, John Kurhanewicz1,
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Graduate Program in Bioengineering, University of California, San Francisco - University of California, Berkeley, Berkeley, CA, United States; 3Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, United States
This study used multi-parametric 1H and hyperpolarized 13C MR imaging in the TRAMP model to investigate early response in perfusion, diffusion and metabolism to the impact of increasing dose levels of radiation therapy. TRAMP mouse were treated with a radiation dose distribution from 14Gy to 5Gy within the tumor. Both 1H (t2-weighted, DCE and DWI) and hyperpolarized 13C ([1-13C] pyruvate and 13C urea) imaging was done before treatment and serially after treatment. HP 13C biomarkers correlated with conventional 1H MR markers. Significant dose dependent changes in perfusion and pyruvate-to-lactate flux were observed following radiation therapy.