Asif
Rizwan1, 2, Inna Serganova3, Xiaohui Ni1,
Sunitha Thakur1, 4, Kristen Zakian1, 4,
Ronald Blasberg3, 4, Jason Koutcher1, 4
1Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Physiology and Biophysics, Weill Cornell Medical College, New York, NY, United States; 3Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 4Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States
Metabolic changes in primary tumors can lead to the development of the metastatic phenotype. The objective of this study is to demonstrate the link between LDH-A expression and lactate level in tumors. The LDH-A silenced 4T1 tumors have slower growth rate compare to the control 4T1 tumors. Both nonlocalized- and localized-spectra are acquired using the selective multiple-quantum coherence transfer (SelMQC) sequence in vivo. The LDH-A silenced 4T1 tumors showed a lower level of lactate compare to 4T1 control tumors.