1Radiology, Hannover Medical School, Hannover, Germany; 2Nephrology, Hannover Medical School, Hannover, Germany; 3Institute of Animal Science, Hannover Medical School, Hannover, Germany
We investigated whether arterial spin labeling (ASL) allows monitoring renal perfusion impairment after acute kidney injury (AKI) in mice. Moderate and severe AKI were induced and renal blood flow (RBF) was measured by ASL using a 7T scanner. At day 7, RBF was significantly reduced after moderate and severe AKI. RBF returned to baseline at d28 after moderate, whereas it remained significantly reduced after severe AKI. RBF-changes correlated with impairment of renal function, renal fibrosis and kidney volume loss. Thus, ASL may help to non-invasively detect renal perfusion impairment and presence and severity of AKI at an early time point.