Tuukka Miettinen1, Alejandra Sierra1, Teemu Laitinen2, Juhana Sorvari1, Olli Grhn3
1Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland; 2Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland; 3Department of Neurobiology, University of Eastern Finland, Kuopio, Finland
Parametric maps obtained with double-PFG MR imaging and DTI were compared in five brain regions with different degree of microscopic and microscopic anisotropy as verified by histology. Our data show clear difference between FA and apparent eccentricity (|aE|) map in white matter while the residual phase map from d-PFG data could differentiate between grey matter areas with different degrees of partially oriented anisotropic structures. We conclude that double-PFG can provide novel information about microstructure of tissue and it has high potential to detect structural modifications caused by pathological conditions.