Mathieu David Santin1,
2, Thomas Debeir3, Thierry Delzescaux2, 4,
Anne-Sophie Herard2, 4, Caroline Cohen3,
Laurent Pradier3, Thomas Rooney3, Marc Dhenain2,
4
1Centre
de Neuroimagerie de Recherche CENIR, Institut du Cerveau et de la Moelle
pinire ICM, Paris, France; 2URA 2210 CEA/CNRS,
Fontenay-aux-Roses, France; 3Therapeutic Strategy Unit Aging,
Sanofi, Chilly-Mazarin, France; 4MIRCen, CEA / I2BM,
Fontenay-aux-Roses, France
This work describes the use of Gd-Staining MRI to quantify the efficacy of an immunotherapy in a mouse model of cerebral amyloidosis. We showed that this technique is suitable for longitudinal studies and provided age-associated increase of amyloid plaques in transgenic mice.