1Neurophysics, Max-Plank Institute for Human Cognitive and Brain Sciences, Leipzig, Saxonia, Germany; 2Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia
Beside the classical blood oxygenation level dependent (BOLD) contrast methods, cerebral blood volume (CBV) and cerebral blood flow (CBF) based functional MRI (fMRI) measurements have recently become frequently used tools in neuroscience. However, the quantitative relationships between each of these parameters is not yet fully understood. We present an fMRI technique that simultaneously measures CBV, CBF and BOLD signals. This method benefits from the high static magnetic field strength of 7T as well as the implementation of slab-selective VASO and a multiple EPI-readout in order to correct for BOLD contamination effects in the CBV- and CBF weighted MRI signals.