Abstract #0114

Early Increases in Glu/Gln, Tau and TCho 1H MRS Resonances in vivo, Anticipate Later Imaging Repercussions of the Cerebral Inflammatory Response in a Mouse Model of LPS-Induced Endotoxemia

Ana Belen Martn-Recuero¹, Agnieszka Krzyzanowska², Pilar Lpez-Larrubia¹, Carlos Avendao², Sebastin Cerdn³

¹Laboratorio de Modelos Animales, Instituto Investigaciones Biomdicas Alberto Sols CSIC-UAM, Madrid, Spain; ²Anatomy, Histology & Neuroscience, Medical School, Autonoma Univ. of Madrid, Spain, Madrid, Spain; ³Laboratorio de Modelos Animales, Instituto de Investigaciones Biomdicas - CSIC, Madrid, Spain

Cerebral inflammation underlies the most morbid and prevalent neurological disorders, including cancer, ischemia or neurodegeneration. However, the inflammatory component remains difficult to differentiate from the intrinsic pathology by most bioimaging methods, since in-vivo biomarkers of the inflammatory phenotype have not been characterized. With this aim, we report a longitudinal MRI and MRS characterization of the cerebral inflammatory component developed after systemic administration of LPS, an inflammation model devoid of additional intrinsic pathologies. Our results revealed that inflammation is characterized by early, severe, spectroscopic changes in Glu/Gln, tCho, Tau and Lac resonances, anticipating those detected later by multi-parametric MRI.