Jasper van Tiel1, 2, Esther Bron1, 3, Koen Bos2, Stefan Klein1, 3, Max Reijman2, Jan Verhaar2, Gabriel Krestin1, Harrie Weinans2, 4, Gyula Kotek1, Edwin Oei1
1Radiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 2Orthopedic Surgery, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 3Medical Informatics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands; 4Biomechanical Engineering, Delft University of Technology, Delft, Zuid-Holland, Netherlands
We investigated the relation between delayed contrast-enhancement of an ionic contrast agent in the meniscus and adjacent cartilage in early stage knee osteoarthritis patients. We observed a moderate to strong relation between contrast uptake into both structures after a 1.5 hour delay. This finding is in agreement with the outcomes of previous research in which semi-quantitative whole joint assessment on MR images showed a relation between meniscal damage and cartilage loss. However, our results also raise a question about the specificity of delayed gadolinium-enhanced MRI of cartilage for sGAG content in (osteoarthritic) cartilage.