1Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States; 2Radiology, Hosptial das Clinicas-FMUSP, School of Medicine - University of Sao Paolo, Sao Paolo, SP, Brazil; 3Radiology, Cancer Institute, New York University School of Medicine, New York, NY, United States; 4Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States
Although DCE-MRI is an important tool for high-risk screening of breast cancer lesions, its suboptimal specificity results in many unnecessary biopsies. In this study, we investigate the use of pharmacokinetic analysis for discrimination of lesion types in a population of patients referred for biopsy. This population is particularly problematic since standard clinical analysis has already failed for this group. Our analysis shows that Ktrans and ve show noticeable differences between lesion types in this patient group, however, refinement of the analysis methods is necessary to further improve the separation of lesion types for this challenging cohort.