Abstract #0214

in vivo Spectroscopic Imaging of 2-Hydroxyglutarate in Human Gliomas at 7.0 T

Sandeep Ganji¹, Keith M. Hulsey¹, Elizabeth A. Maher²,³, Changho Choi⁴

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; ²Harold C. Simmons Cancer Center,, UT Southwestern Medical Center, Dallas, TX, United States; ³Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; ⁴Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

We report the first in vivo spectroscopic imaging of 2HG at 7T using an optimized echo-time PRESS-based localization method in subjects with brain tumors. We present phantom and in vivo data and show the elevated 2HG levels in tumor patients. Metabolites concentration maps are also presented.