Pippa Storey1,
Stephen Honig2, David R. Stoffel1, Sandra L. Moore1
1Radiology
Department, New York University School of Medicine, New York, NY, United
States; 2Division of Rheumatology, New York University School of
Medicine, New York, NY, United States
Early malignant infiltration of bone marrow, characterized by small or diffuse lesions, is difficult to detect using routine sequences. We propose a multiple gradient echo technique to quantify trabecular loss (via R2*) and altered marrow fat content (via chemical shift). For validation purposes, the technique was tested in 6 patients with osteoporosis or osteopenia, using 8 healthy young men as controls. Both fat content and R2* differed significantly between patients and controls (p=0.04 and p=0.0003 respectively). Among patients, fat content and R2* exhibited significant correlations with bone mineral density evaluated by DXA (r=-0.89 with p=0.02, and r=0.88 with p=0.02 respectively).