Saurav Chandra1, Nicole Londraville2, Samuel Cadena2, Erica C. Henning1
1Global Imaging Group, Novartis Institutes for Biomedical Research (NIBR), Cambridge, MA, United States; 2Musculoskeletal Disease Area, Novartis Institutes for Biomedical Research (NIBR), Cambridge, MA, United States
Neurodegeneration is largely a consequence of aging, injury, or disease (eg., amyotrophic lateral sclerosis). Severe neurodegeneration is associated with muscle atrophy, impaired functional capacity, and in some cases, death. In this study, combined T2 and IDEAL MRI permitted non-invasive identification of nerve injury prior to distal muscle inflammation and atrophy, and nerve repair prior to muscle regrowth. This is with high sensitivity and reliability, without contrast agent. These findings provide selection of key time points for target identification and profiling of nerve injury/repair and muscle atrophy/regrowth.