1Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2Biomedical Physics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, United States; 3Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 4Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States; 5Birmingham VA Medical Center, Birmingham, AL, United States
Primary mitral regurgitation (MR) is a common valvular disorder that foments left ventricular (LV) dysfunction. LV twist is a quantitative imaging biomarker for LV dysfunction and was studied in normal subjects and patients with moderate and severe MR. Compared to normal subjects peak LV twist was decreased in moderate and severe MR. No differences were detected in CL-shear angle between the groups. Peak systolic twist-per-volume slope was significantly different for all pairwise comparisons and was decreased in moderate MR and further decreased in severe MR compared to normal subjects. Peak systolic twist-per-volume slope may possibly serve as sensitive imaging biomarker of LV dysfunction in patients with primary MR.