Julia V. Velikina1, Youngkyoo Jung2, Aaron A. Field3, Alexey A. Samsonov3
1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; 2Radiology, Wake Forest University, Winston-Salem, NC, United States; 3Radiology, University of Wisconsin - Madison, Madison, WI, United States
We propose a novel approach to dynamic contrast susceptibility perfusion-weighted imaging using a combination of multi-echo spiral acquisition and compressed sensing-type regularized reconstruction based on 2nd derivative in temporal dimension to overcome limitations of standard EPI-based perfusion imaging technique. The proposed technique allows for a significant increase of in-plane spatial resolution and improved whole-head coverage (voxel size 1.375x1.375x5 mm) without compromising temporal resolution (1.35 ms). Availability of four different echo times allows for unbiased R2* mapping and more accurate/artifact-free estimation of relevant haemodynamic perfusion parameters (cerebral blood volume/flow and mean transit time).