Michael Markl1, Sebastian Berg2, Alex J. Barker1, J Schllhorn2, Martin Schumacher2, Cornelius Weiller2, Andreas Harloff2
1Northwestern University, Chicago, IL, United States; 2University of Freiburg, Freiburg, Germany
Low wall shear stress (WSS) and high oscillatory shear index (OSI) have been linked to the development of atherosclerosis. The purpose of this study was to investigate the impact of carotid endarterectomy on the in-vivo WSS and OSI distribution in the carotid bifurcation. In 20 patients, 4D flow MRI was able to selectively quantify regional 3D hemodynamics in patients before and after intervention for high-grade ICA stenosis. Plaque removals lead to significant reductions of WSS and OSI in the ICA while wall parameters in the CCA and ECA remained largely unchanged demonstrating a localized impact of endarterectomy on carotid hemodynamics.