Christopher D.J. Sinclair1, 2, Jasper M. Morrow1, Robert L. Janiczek3, Michael G. Hanna1, Mary M. Reilly1, Tarek A. Yousry1, 2, Rebecca S. Samson4, Nikolaus Weiskopf5, Antoine Lutti5, David L. Thomas2, Xavier Golay6, John S. Thornton1, 2
1MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom; 2Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 3United Kingdom, GlaxoSmithKline, Brentford, Middlesex, United Kingdom; 4Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 5Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom; 6Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom
Quantitative imaging of skeletal muscle may provide important markers of disease for clinical trials. We used quantitative magnetization transfer (qMT) imaging and the IDEAL-CPMG fat-water separation method to quantify the muscle water-component T2 relaxation times and muscle fat-fraction in the calves of patients with inclusion body myositis. A range of pathologies were observed including isolated T2 elevation, isolated fat-fraction increases or both. QMT parameters, such as the bound pool fraction f, reflected the variations and f was decreased in muscle displaying isolated edema. Further investigation of these relationships may allow the identification of muscles involved early in the disease.