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Abstract #0716

Minimizing the Influence of Blood Volume Fraction on Other Pharmacokinetic Parameters in DCE-MRI

Xin Li1, Jeffrey M. Njus1, Seymur Gahramanov2, Csanad G. Vrallyay2, John W. Grinstead3, Charles S. Springer, Jr. 1, Edward A. Neuwelt2, William D. Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States; 3Siemens Healthcare, Portland, OR, United States


For DCE-MRI, it is possible to obtain consistent Ktrans (CR transfer constant) and ve (extracellular, extravascular volume fraction) values whether incorporating vb (blood volume fraction) or not into DCE-MRI modeling. This often requires minimizing the influence of vb in DCE-MRI data time-courses.