1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Case Cardiovascular Research Institute, Case Western Reserve Univ. and University Hospitals, Cleveland, OH, United States; 3Radiology, University Hospitals Case Medical Center, Cleveland, OH, United States; 4Radiology, Case Western Reserve University, Cleveland, OH, United States
Complete evaluation of both large and small vessels would typically require two separate contrast enhanced acquisitions: MR angiography and dynamic contrast enhanced (DCE) MRI. MRAP (MR Angiography and Perfusion) is a technique that allows for simultaneous acquisition of both these exams by using an optimized, 3D, time-resolved contrast-enhanced acquisition with high spatial/temporal resolution. This preliminary study applies MRAP to the clinical evaluation of peripheral arterial disease (PAD). DCE-MRI perfusion measurements from various muscles in the leg were correlated to ankle brachial index (ABI) data to evaluate the use of MRAP in PAD.