Abstract #0748

Intra-Individual Assessment of the Bolus Properties of 0.5M Gadopentetate Dimeglumine and 1.0M Gadobutrol in Time-Resolved Contrast-Enhanced 4D-MRA and Dynamic CT in a Minipig Model

Dariusch Reza Hadizadeh¹, Gregor Jost², Hubertus Pietsch², Martin Weibrecht³, Marco Lierfeld⁴, Jack Boschewitz¹, Hans H. Schild¹, Winfried Albert Willinek¹

¹Radiology, University of Bonn, Bonn, NRW, Germany; ²MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany; ³Research Laboratories, Philips Technologie GmbH Innovative Technologies,, Aachen, NRW, Germany; ⁴Institute of Imaging & Computer Vision), RWTH Aachen University, Aachen, NRW, Germany

Time-resolved contrast-enhanced MRA (4D-MRA) is more and more applied in various clinical indications and optimization of the applied contrast agent bolus is crucial. The impact of 1molar concentration on vascular gadolinium concentration (dynamic CT) and signal levels (4D-MRA) was investigated in an animal model of 7 Goettinger minipigs. Transversal slices covered the ascending aorta, descending aorta, and pulmonary trunk. Signal levels, the bolus profile and Gd-concentrations were quantified using 1.0M Gadobutrol (1.0GB) and 0.5M gadopentetate dimeglumine (0.5GD). 4D-MRA offered significantly higher signal and dynamic CT allowed for quantification of respectively higher peak Gd-concentrations using 1.0GB vs. 0.5GD.