Shihong Li1, 2, Michael Carl3, Eric Chang1, Won C. Bae1, Christine Chung1, Graeme M. Bydder4, Jiang Du1
1Radiology, University of California, San Diego, San Diego, CA, United States; 2Huadong Hospital, Fudan University, Shanghai, China; 3Global Applied Science Laboratory, GE Healthcare, San Diego, CA, United States; 4Radiology, University of California San Diego, San Diego, CA, United States
Bone is a composite material consisting of mineral, organic matrix and water. There is mounting evidence showing that there are age and disease related changes to the organic matrix. However, there are no techniques available for direct imaging of the organic matrix in vivo. Magnetic resonance imaging (MRI) has been employed to indirectly evaluate the organic matrix via direct imaging of water bound to collagen in cortical bone. In this study we investigated the adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequence to evaluate bone water bound to the organic matrix.