Li An1, Shizhe Li1, Emily T. Wood2, 3, Daniel S. Reich2, 3, Jun Shen1
1National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States; 2NeuroImmunology Branch (NINDS), National Institutes of Health, Bethesda, MD, United States; 3Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States
The accuracy and precision of in vivo measurements of n-acetyl-aspartyl-glutamate (NAAG) are often limited because the NAAG singlet at 2.05 ppm overlaps with the n-acetyl-aspartate singlet at 2.01 ppm and the NAAG multiplet at 2.19 ppm is buried by other signals. In this work, we optimize the TEs of the PRESS sequence to improve NAAG detection at 7T. In addition, we also develop a water reference deconvolution algorithm to enhance spectral resolution by reducing lineshape distortions due to B0 inhomogeneities and residual eddy currents.