1Brain Imaging & Analysis Center, Duke University, Durham, NC, United States; 2GE Healthcare China, Beijing, China; 3Neurology, Medical University of Graz, Graz, Austria; 4Psychiatry and Behavioral Sciences, Durham VA Medical Center, Durham, NC, United States; 5Pediatrics, Duke University, Durham, NC, United States; 6Radiology, Duke University, Durham, NC, United States
The evolution of regional magnetic susceptibility in the human brain is assessed in 181 subjects from 1 to 83 years. The evolution of magnetic susceptibility over the lifespan was found to display differential trajectories between gray and white matter. Both cortical and subcortical white matter showed an initial decrease followed by a subsequent increase of magnetic susceptibility, while both cortical gray matter and iron-rich deep nuclei displays a monotonic increase. These results suggest that magnetic susceptibility may provide valuable information regarding the spatial and temporal patterns of brain myelination and iron deposition during brain maturation and ageing.