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Abstract #0883

Theragnostic Imaging of Micelle-Mediated Rosiglitazone Delivery to Atherosclerotic Plaques

Brigit den Adel1, 2, Sandra Bovens3, Ernst Suidgeest4, Gustav J. Strijkers5, Gerard Pasterkamp3, Robert E. Poelmann2, Louise van der Weerd6, 7

1Pathology, Amsterdam Medical Center, Amsterdam, Netherlands; 2Anatomy, Leiden University Medical Center, Leiden, Netherlands; 3Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 4Radiology, Leiden University Medical Center, Leiden, Netherlands; 5Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 6Radiology , Leiden University Medical Center, Leiden, Netherlands; 7Human Genetics, Leiden University Medical Center, Leiden, Netherlands


This study shows the theragnostic imaging and treatment of atherosclerotis in ApoE-/- and ApoE-/-eNOS-/- mice. The application of non-invasive molecular imaging to monitor drug delivery and therapeutic responses. Rosiglitazone was incorporated in micelles to improve targeting to plaques and reduce the well-known side effects of this drug. Atherosclerotic lesions were reduced after micelle-mediated rosiglitazone therapy, while avoiding the negative side effects associated with conventional rosiglitazone treatment.