Sumit Narayan Niogi1, Daniel Rosenbaum1, Jeffrey Perlman2, Linda Heier1, Arzu Kovanlikaya1
1Radiology, NY Presbyterian Hospital Weill Cornell Medical Center, New York, NY, United States; 2Pediatrics, NY Presbyterian Hospital Weill Cornell Medical Center, New York, NY, United States
Perinatal hypoxic-ischemic encephalopathy causes significant disability in newborns and accounts for about 25% of children with cerebral palsy. As of yet, there is no reliable biomarker to predict which of these infants will have poor outcome. . However, DTI is sensitive to subtle microstructural changes overlooked by conventional imaging. As shown in this study, variations in white matter integrity in specific pathways (the anterior and posterior limbs of the internal capsule and forceps major) can predict clinical outcome after treatment with therapeutic hypothermia.