Yongxia Zhou1, Andrea S. Kierans1, Damon Kenul1, Yulin Ge1, Joseph Rath2, Joseph Reaume1, Robert I. Grossman3, Yvonne W. Lui1
1Radiology and Center for Biomedical Imaging, New York University Langone Medical Center, New York, NY, United States; 2Rusk Institute of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States; 3Radiology and Center for Biomedical Imaging, New York University, New York, NY, United States
The purpose of this study is to investigate longitudinal changes in regional brain volume patients after mild traumatic brain injury (MTBI) one year after injury and to correlate such changes with clinical and neurocognitive metrics. Automated segmentation of brain regions to compute regional gray matter (GM) and white matter (WM) volumes and validation with two advanced imaging techniques were done based on 3D T1-weighted imaging performed at 3T and correlated with clinical metrics. There are regions demonstrating measurable atrophy one year after MTBI, namely the WM in bilateral anterior cingulate and left isthmus of cingulate and precuneal GM.