Qiang Shen1,
Fang Du1, Timothy O. Duong2
1Research
Imaging Institute, University of Texas Health Science Center at San Antonio,
San Antonio, TX, United States; 2Research Imaging Institute, UT
Health Science Center at San Antonio, San Antonio, TX, United States
Cerebral blood flow is an important physiological parameter. The majority of CBF studies in rat brain are ~500x500x2000 microns using single shot EPI. In this study, we targeted the spatial resolution of 50μm x 38μm x 1mm to map the layer specific CBF of rat cortex. This approach was also used to image CBF of stroke rat brain at different time points. This study sets the stage for investigating CBF dysfunction for neurological diseases at very high spatial resolution.