1Electrical & Computer Engineering, Brigham Young University, Provo, UT, United States; 2Oregon Health & Science University, Portland, OR, United States; 3Department of Radiology, University of Utah, Salt Lake City, UT, United States; 4Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States
3D DCE MRI utilizes rapid T1-weighted acquisitions to record the uptake of an injected contrast agent. In the brain, recent developments in pharmacokinetic modeling have enabled the separation of flow and permeability components in these T1-weighted acquisitions, providing a potential alternative to conventional T2*-weighted perfusion MRI. The ability to obtain rapid, high-resolution whole-brain coverage is desirable for a variety of diseases, requiring acceleration factors of 3-4 relative to current state-of-the-art data acquisition schemes. Here, we demonstrate whole brain 3D DCE MRI acquired at 2 mm isotropic resolution and 4.3 sec temporal resolution using a weighted pseudo-random undersampling scheme.