Richard Watts1,
Trevor Andrews1, 2, Scott Hipko1, Jay Gonyea1,
Christopher G. Filippi1, 3
1Department
of Radiology, University of Vermont College of Medicine, Burlington, VT,
United States; 2Philips Healthcare, Cleveland, OH, United States; 3Department
of Radiology, Columbia University Medical Center, New York, NY, United States
T1&[rho] is sensitive to the macromolecular content of biological tissue. Quantitative whole-brain T1&[rho] maps were obtained from 41 control subjects aged 18-76 using a fluid attenuated 3D turbo spin echo technique. T1&[rho] from cortical grey matter showed a negative correlation with age (r=-0.599, p<0.001) major white matter tracts showed a positive correlation (r=0.527, p<0.001), and juxtacortical white matter showed no significant correlation (r=0.035, p=0.830). This study presents the first systematic study of T1&[rho] in normal aging, and provides normative data for future studies of disease pathology.