Aikaterini Kotrotsou1, David A. Bennett2, Julie A. Schneider2, Tom Golak1, Konstantinos Arfanakis1, 2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States
The aims of this work were to: 1) longitudinally assess the volume of various gray matter regions measured with ex-vivo MRI, and 2) investigate the relationship between volumetric measurements performed in-vivo and ex-vivo on the same subjects. No significant change was detected in the volume of gray matter structures over time postmortem. A statistically significant linear relationship was detected between the volumes of brain regions measured ex-vivo and in-vivo on the same subjects. Combination of ex-vivo MR volumetry and histopathology may become an effective tool for the assessment of the neuropathologic correlates of macrostructural brain abnormalities observed in-vivo.