Robert Westphal1, Camilla Simmons1, Michel B. Mesquita1, Tobias C. Wood1, William R. Crum1, Denise Duricki1, Anthony Vernon2, Steve C.R. Williams1, Diana Cash1
1Neuroimaging, King's College London, Institute of Psychiatry, London, United Kingdom; 2Psychosis Studies, King's College London, Institute of Psychiatry, London, United Kingdom
Animal models such as 6-OHDA lesioning in rats are crucial for our understanding of Parkinsons disease and serve as an ideal test-bed for therapeutic interventions. In an attempt to further characterize the 6-OHDA rat, we employed pharmacological MRI and structural MRI, revealing new features such as thalamic & cortical functional impairments and structural changes in the brain stem and the frontal cortex. These results give new insights into the mechanisms of pathology in this model, which may broaden its application for novel therapeutic treatments.