Kathryn L. West1, Mark D. Does1, 2
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt.University Institute of Imaging Science , Vanderbilt University, Nashville, TN, United States
Using calculations of the Cramer-Rao Lower Bounds of variance, we determined the tradeoffs of B0 and added contrast agent in Myelin Water Imaging (MWI) of excised rat brain. While image SNR increases with B0 and SNR efficiency increases with [Gd], decreases in T2 make myelin water signals statistically more difficult to fit. Results show a net increase in MWI SNR at 15.2T compared to 7T, but no advantage in loading tissue with Gd.